Test Preparation : No special preparation required

Sample : Paraffin Blocks/Tissue in buffered formalin

Methodlogy : IHC

Description :

WHAT IS IT?

A laboratory procedure called immunohistochemistry CD23 (IHC CD23) is performed to find and see whether the CD23 protein is present in tissue samples. A membrane-bound protein called CD23, often referred to as the low-affinity IgE receptor, is present on the surface of immune cells such as B cells, monocytes, and macrophages. The procedure for the test is coating tissue samples with certain antibodies that bind to the CD23 protein, then detecting the treated samples using techniques like enzymatic reactions or fluorescence. IHC CD23 is essential for understanding immune cell location and interactions in the tissue milieu in immunology and disease. In diseases like chronic lymphocytic leukaemia and B-cell disorders, it is very important. IHC CD23 leads to a thorough understanding of immune responses and cellular dynamics, enhancing disease classification, patient care, and immunopathology research developments.

WHY?

Because it can shed light on immune cell dynamics and the pathophysiology of diseases, the IHC CD23 test is essential in clinical and research contexts. The test aids in the diagnosis and classification of diseases, notably B-cell abnormalities, by identifying and visualizing the CD23 protein inside tissue samples. Pathologists can distinguish between various lymphoma forms and advise on the best course of action. The test advances knowledge of inflammatory and immunological responses within tissues and aids in the study of the functions of immune cells in autoimmune diseases and allergy reactions. Researchers obtain insights into the intricate interactions between the immune system and tissue microenvironments by analyzing the distribution of CD23-positive cells. In general, the IHC CD23 test contributes significantly to our understanding of immune cell behavior and how it affects disease states, supporting precise diagnosis, prognosis evaluation, and therapy planning.

PRECAUTIONS 

Blood samples are used to collect information on patients with CD23 negativity, which may be a sign of Mantle cell lymphoma. Roll up the sleeves of your garment by donning half sleeves or loose-fitting attire. Follow the directions given at the testing site. You will be given information if you need to take immediate action.