Test Preparation : No special preparation required

Sample : Paraffin Blocks/Tissue in buffered formalin

Methodlogy : IHC

Description :

WHAT IS IT?

Biological materials are subjected to the Immunohistochemistry (IHC) Neuron-Specific Enolase (NSE) test, a diagnostic process used to identify and measure neuron-specific enolase, an enzyme typically found in neurons and neuroendocrine cells. An important part of the energy metabolism within neurons is played by the glycolytic enzyme known as neuron-specific enolase, which is frequently employed as a biomarker for injury or malfunction of neuronal and neuroendocrine cells. In the IHC NSE test, certain antibodies are applied to tissue sections, usually taken from biopsy samples or post-mortem tissue, and these tissue sections are then bound to neuron-specific enolase. This test allows for the observation and localization of neuron-specific enolase inside the tissue under a microscope by using a colorimetric or fluorescent labeling technique. As elevated levels of neuron-specific enolase can indicate neuronal injury, neurodegenerative diseases, or malignancies arising from neuroendocrine tissues, the IHC NSE test is frequently used in neuropathology, neurology, and oncology to aid in the diagnosis and monitoring of various neurological disorders and tumors.

WHY?

To find out how much NSE is present in blood serum, a Neuron Specific Enolase test is performed. The following findings are drawn from these tests: In order to diagnose small cell lung cancer, carcinoid, neuroblastoma, pheochromocytoma, retinal astrocytoma, and pancreatic cell carcinoma, the NSE value must be higher than 8.9 mcg per liter according to the test findings. It is impossible to draw any conclusions from this test alone; nevertheless, further supplementary tests are carried out in addition to the clinical results. False findings may occasionally happen as a result of how certain medications or other situations are interpreted.

PRECAUTIONS

No extra preparation is needed before taking the Neuron Specific Enolase test. It is crucial that you let your doctor know about any prescription drugs or dietary supplements you routinely take since they may interfere with the test and result in erroneous findings. Doctors will advise you whether to continue taking them or cease doing so in advance. There is no requirement for the patients to fast before to the test because it is a blood test, however the majority of them will be doing so. Except as directed by a physician, there are no specific dietary restrictions to be observed before to the test.